12/10/2023 0 Comments Vox djs sky park![]() The majority of patients are diagnosed with KTCN at an early age, usually in the second decade of life. Based on the performed meta-analysis, the frequency of 1.3/1000 in the general population was estimated. One of the lowest incidence rates (0.0068%) was reported in North Macedonia and the highest (4.79%) in pediatric patients in Saudi Arabia. KTCN affects all ethnic groups worldwide and the disease prevalence varies between the described populations. Penetrating keratoplasty, deep anterior lamellar keratoplasty, and Bowman layer transplantation are treatment options in the advanced stages of the disease. Progression of KTCN can be modified–slowed down with corneal cross-linking procedure (CXL), which normalizes corneal parameters and improves visual acuity. Visual function support is provided with eyeglasses, contact lenses, or intrastromal corneal ring segments (ICRS). Compound myopic astigmatism is the most prevalent refractive error in the manifest refraction in KTCN patients, followed by hyperopic compound, mixed and myopic astigmatism. The usage of state-of-the-art technologies extends this definition to include detected abnormalities in both posterior corneal elevation and corneal thickness distribution, as well as in the corneal epithelium thickness profile. Keratoconus (KTCN) is a bilateral corneal disease characterized by progressive thinning and scarring of the cornea, iron deposition, and breaks in Bowman’s layer. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. Next-generation sequencing was performed thanks to Genomics Core Facility CeNT UW using the NovaSeq 6000 platform financed by the Polish Ministry of Science and Higher Education (decision no. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All proceeded clinical/environmental/behavioral/socioeconomic/molecular data, as minimal data set underlying the results described in our manuscript, are shared in a public repository Zenodo (DOI: 10.5281/zenodo.7635600 ).įunding: Supported by National Science Centre in Poland ( ), Grants 2018/31/B/NZ5/03280 (to MG) and 2021/41/B/NZ5/02245 (to MG). ![]() Received: DecemAccepted: ApPublished: April 13, 2023Ĭopyright: © 2023 Jaskiewicz et al. PLoS ONE 18(4):Įditor: Georgios Labiris, Democritus University of Thrace, GREECE Eye-rubbing causes CE damage and triggers cellular stress which through its influence on cell apoptosis, migration, and adhesion affects the KTCN phenotype.Ĭitation: Jaskiewicz K, Maleszka-Kurpiel M, Michalski A, Ploski R, Rydzanicz M, Gajecka M (2023) Non-allergic eye rubbing is a major behavioral risk factor for keratoconus. Presented findings support the hypothesis of chronic mechanical corneal trauma in KTCN. ![]() Genes whose expression was extrapolated to the allergy status didn’t contribute to IgE-related or other inflammatory pathways. Analyses for genes whose expression in the CE was correlated with the eye rubbing manner showed the enrichment in apoptosis ( TP53, BCL2L1), chaperon-related ( TLN1, CTDSP2, SRPRA), unfolded protein response ( NFYA, TLN1, CTDSP2, SRPRA), cell adhesion ( TGFBI, PTPN1, PDPK1), and cellular stress ( TFDP1, SRPRA, CAPZB) pathways. ![]() Male sex, eye rubbing, time of using a computer after work, and dust in the working environment, were the substantial KTCN risk factors identified in multivariate analysis, with ORs of 8.66, 7.36, 2.35, and 5.25, respectively. Selected KTCN-specific findings were correlated with the outcomes of the RNA-seq assessment of the CE samples. In this case-control study, 118 KTCN patients and 73 controls were clinically examined and the Questionnaire covering the aforementioned aspects was completed and then statistically elaborated. Since the environmental, behavioral, and socioeconomic factors in the etiology of keratoconus (KTCN) remain poorly understood, we characterized them as features influencing KTCN phenotype, and especially affecting the corneal epithelium (CE).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |